Yan Chang Selected Research

Immunoglobulin D (IgD)

2/2022	An IgD-Fc-Ig fusion protein restrains the activation of T and B cells by inhibiting IgD-IgDR-Lck signaling in rheumatoid arthritis.
6/2020	IgD-Fc-Ig fusion protein, a new biological agent, inhibits T cell function in CIA rats by inhibiting IgD-IgDR-Lck-NF-κB signaling pathways.
1/2020	Regulation of T Cell Activities in Rheumatoid Arthritis by the Novel Fusion Protein IgD-Fc-Ig.
12/2019	Immunoglobulin D (IgD) and IgD receptor expression in diffuse large B-cell lymphoma.
11/2017	The immunoglobulin D Fc receptor expressed on fibroblast-like synoviocytes from patients with rheumatoid arthritis contributes to the cell activation.
1/2016	The Elevated Secreted Immunoglobulin D Enhanced the Activation of Peripheral Blood Mononuclear Cells in Rheumatoid Arthritis.
1/2016	hIgD promotes human Burkitt lymphoma Daudi cell proliferation by accelerated G1/S transition via IgD receptor activity.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Yan Chang Research Topics

Disease

23	Experimental Arthritis 06/2022 - 02/2007
21	Arthritis (Polyarthritis) 07/2022 - 01/2011
20	Neoplasms (Cancer) 02/2022 - 04/2002
16	Rheumatoid Arthritis 07/2022 - 09/2010
10	Leukemia 01/2018 - 03/2001
9	Inflammation (Inflammations) 07/2022 - 01/2013
9	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 09/2019 - 03/2001
8	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 07/2006 - 06/2000
5	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 08/2012 - 03/2001
4	Autoimmune Diseases (Autoimmune Disease) 12/2019 - 01/2011
3	Esophageal Neoplasms (Esophageal Cancer) 02/2022 - 01/2018
3	Melanoma (Melanoma, Malignant) 01/2020 - 07/2008
3	Hypoxia (Hypoxemia) 10/2016 - 06/2009
3	Residual Neoplasm 08/2012 - 11/2005
2	Carcinogenesis 11/2021 - 04/2020
2	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 01/2020
2	Prostatic Neoplasms (Prostate Cancer) 01/2021 - 12/2019
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 04/2020 - 01/2018
2	Testicular Neoplasms (Testicular Cancer) 01/2020 - 12/2017
2	Necrosis 02/2019 - 12/2013
2	Multiple Myeloma 12/2017 - 09/2005
2	Breast Neoplasms (Breast Cancer) 04/2016 - 01/2002
2	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2016 - 10/2015
2	Allergic Contact Dermatitis 02/2015 - 12/2013
2	Hepatocellular Carcinoma (Hepatoma) 05/2012 - 07/2010
2	Infections 12/2010 - 06/2009
1	Esophageal Squamous Cell Carcinoma 02/2022
1	Gastroesophageal Reflux (GERD) 01/2022
1	Metaplasia 01/2022
1	Wounds and Injuries (Trauma) 01/2022
1	Barrett Esophagus (Barrett's Esophagus) 01/2022

Drug/Important Bio-Agent (IBA)

14	Proteins (Proteins, Gene)FDA Link 02/2022 - 02/2002
8	Therapeutic UsesIBA 10/2021 - 05/2011
8	Pharmaceutical PreparationsIBA 01/2021 - 06/2004
7	Immunoglobulin D (IgD)IBA 02/2022 - 01/2016
7	Messenger RNA (mRNA)IBA 01/2016 - 06/2001
6	AntigensIBA 01/2020 - 02/2002
6	peoniflorinIBA 08/2019 - 10/2011
6	Biological ProductsIBA 06/2019 - 04/2003
6	GlucosidesIBA 08/2016 - 02/2007
5	Methotrexate (Mexate)FDA LinkGeneric 06/2022 - 05/2013
5	CalciumIBA 02/2022 - 01/2016
5	B-Cell Activating FactorIBA 06/2019 - 05/2011
5	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2013 - 09/2001
4	paeoniflorin-6'-O-benzenesulfonateIBA 07/2022 - 01/2016
4	Immunoglobulin G (IgG)IBA 10/2021 - 05/2011
4	CytokinesIBA 01/2021 - 12/2013
4	Monoclonal AntibodiesIBA 04/2016 - 10/2002
4	AntibodiesIBA 05/2012 - 10/2002
3	Interleukin-17 (Interleukin 17)IBA 02/2022 - 12/2013
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2021 - 09/2010
3	Amyloid (Amyloid Fibrils)IBA 01/2021 - 01/2020
3	LigandsIBA 01/2020 - 05/2011
3	Dinoprostone (PGE2)FDA Link 12/2019 - 11/2014
3	G-Protein-Coupled Receptor Kinase 2IBA 12/2019 - 02/2019
3	Telomerase (Telomerase Reverse Transcriptase)IBA 10/2016 - 06/2009
3	20- O- (beta- D- glucopyranosyl)- 20(S)- protopanaxadiolIBA 07/2016 - 10/2014
3	TACI receptor-IgG Fc fragment fusion proteinIBA 05/2013 - 05/2011
2	RP4010IBA 02/2022 - 01/2018
2	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 01/2020
2	RNA (Ribonucleic Acid)IBA 01/2021 - 01/2021
2	Cell Surface ReceptorsIBA 01/2020 - 12/2019
2	Peptides (Polypeptides)IBA 01/2020 - 01/2018
2	immunoglobulin D receptorIBA 12/2019 - 01/2016
2	ProstaglandinsIBA 08/2019 - 05/2012
2	Immunoglobulins (Immunoglobulin)IBA 06/2019 - 11/2017
2	Immunoglobulin A (IgA)IBA 01/2019 - 05/2012
2	IntegrinsIBA 01/2018 - 06/2000
2	NF-kappa B (NF-kB)IBA 01/2018 - 09/2005
2	Bortezomib (Velcade)FDA Link 12/2017 - 09/2005
2	Indicators and Reagents (Reagents)IBA 04/2016 - 07/2010
2	Caspase 3 (Caspase-3)IBA 08/2015 - 09/2005
2	Freund's AdjuvantIBA 03/2015 - 02/2015
2	Interleukin-2 (IL2)IBA 02/2015 - 12/2013
2	Interleukin-4 (Interleukin 4)IBA 02/2015 - 12/2013
2	Interleukin-10 (Interleukin 10)IBA 02/2015 - 12/2013
2	OzoneIBA 01/2015 - 01/2013
2	NucleophosminIBA 07/2013 - 02/2009
2	cryptotanshinoneIBA 12/2011 - 12/2009
2	Collagen Type II (Type II Collagen)IBA 01/2011 - 05/2010
2	NucleotidesIBA 09/2009 - 06/2009
2	Imatinib Mesylate (Gleevec)FDA Link 11/2005 - 01/2005
2	Complementary DNA (cDNA)IBA 07/2004 - 04/2002
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 07/2022
1	Antineoplastic Agents (Antineoplastics)IBA 02/2022
1	Type C PhospholipasesIBA 02/2022
1	Tyrosine Kinase InhibitorsIBA 02/2022
1	AfatinibIBA 02/2022
1	CD40 Ligand (CD40L)IBA 02/2022
1	Tryptophan (L-Tryptophan)FDA Link 01/2022
1	Allopurinol (Remid)FDA LinkGeneric 01/2022
1	EnzymesIBA 01/2022
1	AcidsIBA 01/2022
1	Tryptophan Oxygenase (Tryptophan 2,3 Dioxygenase)IBA 01/2022
1	Bile Acids and Salts (Bile Acids)IBA 01/2022

Therapy/Procedure

15	Therapeutics 02/2022 - 09/2005
5	Drug Therapy (Chemotherapy) 02/2022 - 06/2001
2	Immunotherapy 01/2020 - 04/2016
2	Intradermal Injections 03/2015 - 02/2015
2	Oral Administration 02/2015 - 05/2010